CHARLS数据库发文热点指标

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指标1:Triglyceride Glucose

甘油三酯-葡萄糖指数

计算公式:ln(空腹甘油三酯(mg/dl)×空腹血糖(mg/dl)/2)

指标简介:TyG指数是一种基于空腹甘油三酯与空腹血糖水平计算得出的新兴生物标志物,已被广泛验证可作为胰岛素抵抗的简便有效工具,用于评估个体的代谢健康状况。TyG指数因其依赖常规血液检测项目,具有计算简便、成本低、适用性广等优势,近年来在代谢性疾病筛查与慢性病风险预测中受到越来越多关注。TyG指数不仅与代谢综合征、2型糖尿病、超重和肥胖密切相关,也被发现与心血管疾病的发生与进展存在显著关联。

 案例文章 

标题:Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study 

期刊:Cardiovasc DiabetolIF=8.5

PMID:38017519

标题:The interaction between triglyceride-glucose index and visceral adiposity in cardiovascular disease risk: findings from a nationwide Chinese cohort 

期刊:Cardiovasc DiabetolIF=8.5

PMID:39604987

标题:Joint association of triglyceride glucose index (TyG) and body roundness index (BRI) with stroke incidence: a national cohort study

期刊:Cardiovasc DiabetolIF=8.5

PMID:40241070

指标2:Atherogenic Index of Plasma 

血浆致动脉粥样硬化指数

计算公式:AIP=log10(TG/HDL.C)

指标简介:AIP是评估动脉粥样硬化及心血管疾病风险的重要生物标志物,由甘油三酯(TG)与高密度脂蛋白胆固醇(HDL-C)计算得出,能更准确地反映脂质代谢的整体状态。AIP在传统血脂指标基础上具有更强的预测能力,具备良好的独立性和临床可操作性,尤其适用于高风险人群的早期筛查与心血管健康评估。

 案例文章 

标题:Correlation between atherogenic index of plasma and cardiovascular disease risk across Cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study

期刊:Cardiovasc DiabetolIF=8.5

PMID:39856691

标题:Association between atherogenic index of plasma and cognitive impairment in middle-aged and older adults: results from CHARLS

期刊:Front Aging NeurosciIF=4.1

PMID:40078639

标题:Association between atherogenic index of plasma, body mass index, and sarcopenia: a cross-sectional and longitudinal analysis study based on older adults in China

期刊:Aging Clin Exp ResIF=3.4

PMID:40192974

指标3:Body Roundness Index

身体圆度指数

计算公式:364.2-365.5×√(1-[腰围/2π]²/[0.5×身高]²)

指标简介:BRI是一种基于身高和腰围的体脂评估指标,用于估算个体内脏脂肪的堆积程度。与传统的体重指数(BMI)相比,其不依赖体重计算,而更侧重于脂肪分布,因此在识别中心性肥胖及预测代谢综合征(如心血管疾病、糖尿病)方面具有更高敏感性。BRI的评分范围通常为1–15,理想区间为3.5–5.5。作为BMI的有力补充或替代,BRI在临床和流行病研究中被广泛用于评估肥胖相关健康风险。

 案例文章 

标题:Associations of Body-Roundness Index and Sarcopenia with Cardiovascular Disease among Middle-Aged and Older Adults: Findings from CHARLS

期刊:J Nutr Health AgingIF=4.3

PMID:37997715

标题:Body Roundness Index Trajectories and the Incidence of Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study

期刊:J Am Heart AssocIF=5.0

PMID:39319466

标题:Joint association of triglyceride glucose index (TyG) and body roundness index (BRI) with stroke incidence: a national cohort study

期刊:Cardiovasc DiabetolIF=8.5

PMID:40241070

指标4:Frailty 虚弱

指标简介:虚弱(Frailty)是指一种与年龄相关的综合性健康衰退状态,表现为多系统功能储备下降,使个体在遭遇压力事件时更易发生不良结局,如跌倒、住院或死亡。虚弱的评估主要有两种方法:一是表型法,如Fried等提出的五项指标(体重意外下降、握力减低、自诉疲乏、行走缓慢和体力活动减少),符合三项及以上即判定为虚弱;二是虚弱指数法(Frailty Index,FI),基于与年龄相关的多项健康缺陷的累积,通过将患有的缺陷数除以总评估项数(如32项)计算得分,范围为0–100,FI≥25通常被认为是虚弱。虚弱综合反映了个体在身体、心理和疾病层面的健康缺陷,是流行病学和老年医学研究中常用的评估指标。

 案例文章 

标题:Association of frailty and its trajectory with the risk of cancer: evidence from the China health and retirement longitudinal study (CHARLS)

期刊:BMC Public Health IF=3.5)

PMID: 40375252

标题:Development and validation of a preliminary clinical support system for measuring the probability of incident 2-year (pre)frailty among community-dwelling older adults: A prospective cohort study 

期刊:International Journal of Medical InformaticsIF=3.7

PMID: 37516037

标题:Air pollution increases the risk of frailty: China Health and Retirement Longitudinal Study (CHARLS) 

期刊:J Hazard MaterIF=12.2

PMID: 40187242

指标5:Metabolic Syndrome

代谢综合征

指标简介:代谢综合征(Metabolic Syndrome, MetS)是一组相互关联的代谢异常状态,包括中心性肥胖、高血糖、高血压、高甘油三酯血症和低高密度脂蛋白胆固醇血症。其诊断依据通常为上述五项指标中满足任意三项。MetS是现代慢性病的高危前期状态,显著增加心血管疾病、糖尿病、中风的风险。随着生活方式变化和肥胖流行,MetS患病率逐年上升,已成为全球公共健康的重要挑战。

 案例文章 

标题:Estimating the impact of metabolic syndrome on low back pain and the joint effects of metabolic syndrome and depressive symptoms on low back pain: insights from the China Health and Retirement Longitudinal Study 

期刊:BMC Public HealthIF=3.5

PMID: 39215306

标题:Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study 

期刊:Cardiovasc DiabetolIF=8.5

PMID: 39152431

标题:Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China Health and Retirement Longitudinal Study 

期刊:Eur J Prev CardiolIF=8.4

PMID: 40272444


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